The ROCVIDEO project
Rocuronium versus remifentanil for optimising conditions for video-laryngoscopy assisted tracheal intubation.
Project Status:
Recruiting
from November 2025
Background
Everyone, from children to adults, may need general anaesthesia for procedures like cancer treatment, tonsil removal, or after injuries. To keep the patient breathing safely, anaesthetists place a plastic tube in the windpipe and connect it to a ventilator—a process called intubation. Although common, intubation is the leading cause of anaesthesia-related complications. Two drugs are typically used to make intubation easier, but we don’t know which is safer or more effective when using modern video tools to guide the tube.
Intervention
2,648 participants undergoing general anaesthesia with orotracheal intubation will be randomised 1:1 to either:
A
0.6 mg/kg of ideal body weight rocornium
B
4 µg/kg (2 µg/kg for elder patients) of ideal body wight remifentanil
Intervention will be giving during anaesthesia induction as part of a standard induction regimen.
Study Design
The ROCVIDEO Trial is a investigator-initiated, pragmatic, randomised, blinded, controlled multicentre trial.
The two co-primary outcomes are:
1. Patient related safety outcome: A composite of one or more intubation or anaesthesia related adverse events:
2. Efficacy outcome: Prevalence of failed first-pass intubation.
The secondary outcomes are patient satisfaction scores (QoR-15), Proportions of partici-pants with one or more serious adverse events within first 7 days and lengths of stay in the post-anaesthesia care unit.